circRNA basic information
circBase ID: hsa_circ_0023919
Name: hsa_circ_PICALM
Synonym: -
Host Gene: PICALM
Genomic location(hg19): chr11:85707868-85714494:-
Genomic location(hg38): chr11:85996825-86003451:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum; plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promotes chemoresistance
Molecular mechanism: -
Biological pathway or process:

chemoresistance (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study
Clinical significance:

Serum/plasma hsa_circ_0023919 is elevated in chemoresistant CRC, associated with stage, can distinguish chemoresistance (ROC AUC 0.8977), and higher expression is linked to decreased OS and PFS.
Description:

Serum/plasma hsa_circ_0023919 is up-regulated in CRC, especially in chemoresistant patients, and correlates with TNM stage. Higher hsa_circ_0023919 is associated with worse OS/PFS and shows diagnostic value for chemoresistance (ROC AUC ~0.90), suggesting it promotes chemoresistance and may serve as a therapeutic target.
Confidence score:

0.4992
Other information
Title:

Serum Hsa_circ_0023919 is a Predictive Biomarker of Chemoresistance in CRC Treatment.

Journal: International journal of general medicine
Published: 2024
PubMed ID: 39759896
Study type:

combined biological and clinical study
Data availability: -
Code availability: -