circRNA basic information
circBase ID: -
Name: hsa_circ_VRK1
Synonym: circVRK1
Host Gene: VRK1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MCF-7; MDA-MB-231
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: limits cell growth and promotes apoptosis
Molecular mechanism: not specified
Biological pathway or process:

apoptosis (promotes); drug resistance (other)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection
Clinical significance:

a good response to the drug linked to a more favorable prognosis
Description:

In breast cancer cell lines exposed to anticancer drugs, circVRK1 is generally increased while linVRK1 decreases. circVRK1 is described as limiting cell growth and promoting apoptosis, suggesting association with effective drug response.
Confidence score:

0.2586
Other information
Title:

Inverse Impact of Cancer Drugs on Circular and Linear RNAs in Breast Cancer Cell Lines.

Journal: Non-coding RNA
Published: 2023
PubMed ID: 37218992
Study type:

biological research
Data availability: All data used to support the conclusions are included in the manuscript.
Code availability: -