circRNA basic information
circBase ID: hsa_circ_0043256
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr17:35604934-35609962:-
Genomic location(hg38): chr17:37248010-37253036:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissue; adjacent healthy tissue; tumor-adjacent tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PTEN, MAPK8, MDM2, CDKN1A, IGF1R, RB1, GRB2, ATF3, ITCH, SGK1
Associated microRNA: miR-1252-5p, miR-494-3p, miR-558
Biological function: Predicted tumor suppressor circRNA in NSCLC involved in ceRNA-mediated regulation of cell cycle, inflammatory response, proliferation, and apoptosis.
Molecular mechanism: Predicted ceRNA mechanism in which hsa_circ_0043256 sponges miR-1252-5p, miR-494-3p, and miR-558 and participates in a circRNA-miRNA-target mRNA network.
Biological pathway or process:

ceRNA regulation (other); apoptosis (promotes); proliferation (inhibits); cell cycle (other); inflammation (other); PI3K/AKT (other); AMPK (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

Expression level could be used for patient diagnosis and prognosis prediction, according to the authors' bioinformatics-based discussion.
Description:

hsa_circ_0043256 was downregulated in NSCLC tissues in three GEO circRNA microarray datasets. The study predicts that it sponges miR-1252-5p, miR-494-3p, and miR-558 and participates in a circRNA-miRNA-mRNA network linked to cancer-related pathways and possible diagnostic/prognostic value.
Confidence score:

0.1768
Other information
Title:

Bioinformatics Analysis Predicts hsa_circ_0026337/miR-197-3p as a Potential Oncogenic ceRNA Network for Non-Small Cell Lung Cancers.

Journal: Anti-cancer agents in medicinal chemistry
Published: 2022
PubMed ID: 34254931
Study type:

bioinformatics study
Data availability: GSE158695; GSE112214; GSE101684; CSCD; ENCORI
Code availability: -