| Expression pattern: |
DN |
| Associated gene: |
p-Akt, E-cadherin |
| Associated microRNA: |
miR-1228 |
| Biological function: |
Circ_0004417 inhibits prostate cancer cell proliferation, colony formation, and invasion; its lower expression is associated with increased primary tumor volume and lymph node metastasis. |
| Molecular mechanism: |
Circ_0004417 acts as a sponge for miR-1228 and modulates p-Akt and E-cadherin expression in prostate cancer cells. |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits); metastasis (inhibits); EMT (other); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot |
| Clinical significance: |
Circ_0004417 can be used as a potential therapeutic target for prostate cancer; low expression is associated with larger primary tumor volume and lymph node metastasis. |
| Description: |
Circ_0004417 is down-regulated in prostate cancer tissues and cell lines. Its overexpression suppresses prostate cancer cell proliferation, colony formation, and invasion, likely by sponging miR-1228 and regulating the p-Akt/E-cadherin axis. The study suggests circ_0004417 may serve as a potential therapeutic target for prostate cancer. |
| Confidence score: |
0.7164 |