circRNA basic information
circBase ID: hsa_circ_0003074
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr10:12123470-12133683:+
Genomic location(hg38): chr10:12081471-12091684:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

osteosarcoma cancer tissues; adjacent tissues; peripheral blood; serum; plasma
Cell lines:

hFOB1.19; HOS; SJSA-1; 143B; MG-63; U2OS
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Associated with osteosarcoma severity, relapse, and chemoresistance; high expression indicates worse prognosis.
Molecular mechanism: -
Biological pathway or process:

chemoresistance (other); metastasis (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study
Clinical significance:

Diagnostic biomarker (AUC=0.93) and prognostic biomarker; high expression associated with lower OS and PFS and is an independent prognostic factor.
Description:

hsa_circ_0003074 is up-regulated in osteosarcoma tissues and blood and is elevated in osteosarcoma cell lines. High hsa_circ_0003074 supports osteosarcoma diagnosis (AUC 0.93) and predicts worse prognosis with reduced OS and PFS; its level is associated with tumor size, lung metastasis, relapse, and chemotherapy resistance.
Confidence score:

0.5416
Other information
Title:

Up-Regulation of circRNA hsa_circ_0003074 Expression is a Reliable Diagnostic and Prognostic Biomarker in Patients with Osteosarcoma.

Journal: Cancer management and research
Published: 2020
PubMed ID: 33061621
Study type:

combined biological and clinical study
Data availability: -
Code availability: -