| Expression pattern: |
DN |
| Associated gene: |
FOXO3a, Ago2 |
| Associated microRNA: |
miR-182-5p |
| Biological function: |
hsa_circ_0025202 acts as a tumor suppressor in HR-positive breast cancer, inhibits cell proliferation, colony formation and migration, promotes apoptosis, suppresses xenograft tumor growth, and increases tamoxifen sensitivity. |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0025202 sponges miR-182-5p and regulates FOXO3a expression and activity, thereby suppressing tumor progression and sensitizing breast cancer cells to tamoxifen. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); apoptosis (promotes); metastasis (inhibits); ceRNA regulation (other); drug resistance (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; RNA-seq; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Low hsa_circ_0025202 expression in cancer tissues was negatively correlated with lymphatic metastasis and histological grade, and hsa_circ_0025202 was proposed as a potential biomarker/marker for tamoxifen sensitivity or tamoxifen-resistant breast cancer. |
| Description: |
hsa_circ_0025202 is a GAPDH-derived cytoplasmic circRNA that is down-regulated in tamoxifen-resistant MCF7 cells and HR-positive breast cancer tissues. It suppresses tumor progression and enhances tamoxifen sensitivity by sponging miR-182-5p and regulating FOXO3a. Clinically, its low expression is associated with higher histological grade and lymph node metastasis, suggesting biomarker potential for tamoxifen response. |
| Confidence score: |
0.8685 |