| Expression pattern: |
DN |
| Associated gene: |
ADAM9, CAND1, CNOT8, DACH1, EIF3J, RAP2C, RB1, VCAN, SUCO |
| Associated microRNA: |
miR-607, miR-127-5p, miR-1272, miR-1299, miR-1183, miR-217, miR-767-3p, miR-1256 |
| Biological function: |
Potentially involved in axillary lymph node metastasis and cancer-related pathways; may serve as a biomarker to distinguish breast cancer with ALNM from without ALNM. |
| Molecular mechanism: |
Predicted ceRNA network (circRNA-miRNA-mRNA) involving multiple miRNAs and downstream mRNA targets; pathway enrichment suggests involvement in cancer-related pathways. |
| Biological pathway or process: |
cell cycle (other); JAK/STAT (other); other pathway/process (other); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Decreased circ_0000160 is associated with ALNM; ROC AUC 0.7435 to discriminate tissues with ALNM from those without ALNM. |
| Description: |
circ_0000160 is down-regulated in breast cancer tissues with axillary lymph node metastasis and shows diagnostic potential (AUC 0.7435) to distinguish ALNM-positive from ALNM-negative cases. Bioinformatics predicts circ_0000160 participates in a circRNA-miRNA-mRNA (ceRNA) network involving eight candidate miRNAs and cancer-related pathways such as cell cycle and JAK-STAT. |
| Confidence score: |
0.5047 |