circRNA basic information
circBase ID: -
Name: hsa_circ_GFRA1
Synonym: circGFRA1
Host Gene: GFRA1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MCF-7; MDA-MB-231
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: miR-34a
Biological function: sustains cell proliferation and displays anti-apoptotic effects; associated with drug response
Molecular mechanism: ceRNA mechanism via binding miR-34a
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes); drug resistance (other)
Detected method:
Q
Validation methods:

RT-qPCR
Clinical significance:

downregulation by drugs could represent a diagnostic biomarker of effective treatment
Description:

circGFRA1 is a drug-responsive circRNA in breast cancer cell lines; in MDA-MB-231 it is decreased by AMG511 and GSK1070916, interpreted as an effective drug response. The paper cites that circGFRA1 binds miR-34a and is linked to proliferation/anti-apoptosis and poorer survival in triple-negative breast cancer, and proposes its downregulation as a biomarker of effective treatment.
Confidence score:

0.1155
Other information
Title:

Inverse Impact of Cancer Drugs on Circular and Linear RNAs in Breast Cancer Cell Lines.

Journal: Non-coding RNA
Published: 2023
PubMed ID: 37218992
Study type:

biological research
Data availability: All data used to support the conclusions are included in the manuscript.
Code availability: -