| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-1236 |
| Biological function: |
Promotes breast cancer cell growth, clone-forming ability, migration and invasion, and decreases apoptosis; associated with advanced TNM stage, lymph node invasion and dismal prognosis. |
| Molecular mechanism: |
circ_0103552 acts as a miRNA sponge for miR-1236; its oncogenic role is partly dependent on regulation of miR-1236. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis; Survival Analysis; Cohort Study |
| Clinical significance: |
High circ_0103552 expression is associated with more advanced TNM stages, lymph node invasion, lower survival rate, and is an independent prognostic predictor for breast cancer patients. |
| Description: |
circ_0103552 is up-regulated in breast cancer tissues and cell lines and its high expression predicts unfavorable prognosis. Functionally, it promotes breast cancer cell proliferation, colony formation, migration and invasion while inhibiting apoptosis. Mechanistically, circ_0103552 exerts oncogenic activity at least partly by sponging miR-1236. |
| Confidence score: |
0.7396 |