| Expression pattern: |
UP |
| Associated gene: |
ZEB1 |
| Associated microRNA: |
miR-124-3p |
| Biological function: |
promotes paclitaxel resistance, inhibits PTX-triggered apoptosis, and promotes invasion in PTX-resistant gastric cancer cells; circ-PVT1 knockdown increases PTX sensitivity in vitro and in vivo |
| Molecular mechanism: |
circ-PVT1 acts as a miRNA sponge (ceRNA) for miR-124-3p, thereby up-regulating ZEB1 expression and facilitating paclitaxel resistance |
| Biological pathway or process: |
chemoresistance (promotes); apoptosis (inhibits); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circ-PVT1 is up-regulated in paclitaxel-resistant gastric cancer tissues and cells. It promotes PTX resistance by sponging miR-124-3p and thereby increasing ZEB1 expression; circ-PVT1 knockdown restores PTX sensitivity and enhances PTX-induced apoptosis while reducing invasion, including in xenograft models. |
| Confidence score: |
0.6536 |