circRNA basic information
circBase ID: hsa_circ_0060927
Name: hsa_circ_CYP24A1
Synonym: -
Host Gene: CYP24A1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer / CC
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

CC tissues; normal tissues; tumor tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CXCL8, CYP24A1
Associated microRNA: hsa-miR-4428, hsa-miR-4433a-3p, hsa-miR-4667-5p, hsa-miR-4780, hsa-miR-5006-5p, hsa-miR-5588-5p, hsa-miR-6875-3p, hsa-miR-6891-5p, hsa-miR-885-3p
Biological function: Might upregulate CXCL8 by adsorbing miRNAs and was associated with immune cell infiltration in cervical cancer.
Molecular mechanism: Predicted ceRNA mechanism in which hsa circ 0060927 may sponge miRNAs to upregulate CXCL8.
Biological pathway or process:

ceRNA regulation (promotes); immune regulation (other); inflammation (promotes)
Detected method:
S
Validation methods:

circRNA-seq; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa circ 0060927 was identified as an up-regulated cervical cancer circRNA in the predicted circRNA-miRNA-CXCL8 network. It may contribute to CXCL8 upregulation through miRNA sponging and showed correlations with monocytes, macrophage M0 and macrophage M2 infiltration; it was also correlated with its host gene CYP24A1.
Confidence score:

0.3991
Other information
Title:

Identification of an immune signature to predict poor clinical outcome in cervical cancer.

Journal: Epigenomics
Published: 2021
PubMed ID: 33955785
Study type:

combined clinical and bioinformatics study
Data availability: TCGA; GSE55478; GSE44001; GSE63514; UCSC Xena
Code availability: All data and codes are available from the authors upon reasonable request by contacting, S Wang (shizhiwang2009@seu.edu.cn).