| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential blood-based biomarker for gastric cancer diagnosis and prognosis; reduced levels are associated with clinicopathological features, distal metastasis, shorter overall survival, and postoperative recurrence monitoring. |
| Molecular mechanism: |
No mechanistic regulatory pathway was defined; the study suggests that gastric cancer cells may secrete this circRNA into plasma. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Cohort Study; Survival Analysis; RT-ddPCR |
| Clinical significance: |
Low plasma hsa_circ_0061276 was associated with shorter overall survival; postoperative recovery to normal levels was associated with longer disease-free survival; hsa_circ_0061276 contributed to diagnostic performance for gastric cancer, including combined plasma biomarkers. |
| Description: |
hsa_circ_0061276 is downregulated in gastric cancer tissues and preoperative plasma and was one of the top reduced plasma circRNAs in the microarray profile. Its plasma level has diagnostic and prognostic value, with low expression indicating poorer overall survival and postoperative recovery indicating longer disease-free survival. |
| Confidence score: |
0.6954 |