| Expression pattern: |
UP |
| Associated gene: |
ITGA6, E-cadherin, N-cadherin |
| Associated microRNA: |
miR-761, miR-214-3p |
| Biological function: |
Promotes CRC cell proliferation and migration, inhibits apoptosis, and promotes tumor growth in vivo. |
| Molecular mechanism: |
circ_0038718 acts as a miRNA sponge for miR-761 and miR-214-3p to regulate ITGA6 expression, thereby promoting CRC progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); apoptosis (inhibits); EMT (promotes); metastasis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; MTT; EdU Staining; Annexin V/PI Flow Cytometry; Wound Healing Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
High circ_0038718 expression was associated with lower survival rate and a more malignant phenotype in CRC patients; it may provide a new therapeutic target for CRC patients. |
| Description: |
circ_0038718 is up-regulated in colorectal cancer tissues and cell lines, and high expression is associated with poorer patient survival and more malignant clinicopathologic features. Functionally, circ_0038718 promotes CRC cell proliferation, migration and in vivo tumor growth while suppressing apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-761 and miR-214-3p to increase ITGA6 expression. |
| Confidence score: |
0.8238 |