circRNA basic information
circBase ID: hsa_circ_0012673
Name: hsa_circ_DHCR24
Synonym: hsa_ circ_0012673
Host Gene: DHCR24
Genomic location(hg19): chr1:55340765-55341720:-
Genomic location(hg38): chr1:54875092-54876047:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancerous tissues; corresponding noncancerous tissues; matched adjacent normal tissues
Cell lines:

MCF-10A; MCF7; MDA-MB-231; MDA-MB-468; SKBR-3; MDA-MB-453
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SOX4
Associated microRNA: miR-576-3p
Biological function: Promotes breast cancer cell proliferation, migration and invasion; knockdown suppresses malignant behaviors of breast cancer cells.
Molecular mechanism: hsa_circ_0012673 acts as a ceRNA by sponging miR-576-3p, thereby protecting or upregulating SOX4 and promoting malignant behaviors in breast cancer cells.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; Luciferase Reporter Assay; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

Potential diagnostic and therapeutic molecule or biomarker for breast cancer.
Description:

hsa_circ_0012673 is upregulated in breast cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes breast cancer cell proliferation, migration and invasion by sponging miR-576-3p and upregulating SOX4 through a ceRNA mechanism. The study suggests hsa_circ_0012673 may have potential value as a biomarker and therapeutic target for breast cancer.
Confidence score:

0.6536
Other information
Title:

Circular RNA hsa_circ_0012673 Promotes Breast Cancer Progression via miR-576-3p/SOX4 Axis.

Journal: Molecular biotechnology
Published: 2023
PubMed ID: 35794450
Study type:

combined biological and clinical study
Data availability: -
Code availability: -