circRNA basic information
circBase ID: hsa_circ_0001667
Name: hsa_circ_HEATR2
Synonym: circ_0001667
Host Gene: HEATR2
Genomic location(hg19): chr7:810107-814799:+
Genomic location(hg38): chr7:770470-775162:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissues; adjacent tissues; tumor tissues
Cell lines:

MCF-10A; MDA-MB-468; BT549; MCF-7; HUVECs
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: CXCL10, Ago2
Associated microRNA: miR-6838-5p
Biological function: promotes breast cancer cell proliferation and angiogenesis; promotes tumor growth in vivo
Molecular mechanism: ceRNA sponge mechanism: circ_0001667 sponges miR-6838-5p to increase CXCL10 expression
Biological pathway or process:

proliferation (promotes); angiogenesis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Cell Cycle Assay; Colony Formation Assay; Tube Formation Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; In Vivo Animal Model
Clinical significance:

-
Description:

circ_0001667 is up-regulated in breast cancer tissues and cell lines and promotes proliferation and angiogenesis. Mechanistically, it functions as a ceRNA by sponging miR-6838-5p, thereby relieving repression of CXCL10 and enhancing malignant phenotypes, including tumor growth in vivo.
Confidence score:

0.7631
Other information
Title:

Circ_0001667 accelerates breast cancer proliferation and angiogenesis through regulating CXCL10 expression by sponging miR-6838-5p.

Journal: Thoracic cancer
Published: 2023
PubMed ID: 36811283
Study type:

combined biological and clinical study
Data availability: The analyzed data sets generated during the present study are available from the corresponding author on reasonable request.
Code availability: -