circRNA basic information
circBase ID: hsa_circ_0001073
Name: hsa_circ_ACVR2A
Synonym: circACVR2A / Circular RNA ACVR2A
Host Gene: ACVR2A
Genomic location(hg19): chr2:148653869-148657467:+
Genomic location(hg38): chr2:147896300-147899898:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue
Cell lines:

Huh-7; HepG2; Hep3B; LO2; MIHA; HEK-293; HEK293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: COL4A4, CREB1, ERBB4, FN1, KRAS, NTRK2, PIK3R3, PPP2R5E, PI3K, p-PI3K, Akt, p-Akt, FoxO1, p-Foxo1, Bax, Bcl2
Associated microRNA: miR-511-5p
Biological function: promotes proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo
Molecular mechanism: Acts as a miRNA sponge for miR-511-5p, relieving repression of PI3K-Akt pathway-related targets and activating PI3K/AKT/FOXO1 signaling.
Biological pathway or process:

PI3K/AKT (promotes); apoptosis (inhibits); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; TUNEL; Western Blot; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis
Clinical significance:

-
Description:

circACVR2A is up-regulated in HCC cell lines and promotes HCC malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it sponges miR-511-5p, derepressing miR-511-5p targets and activating PI3K/AKT/FOXO1 signaling, thereby promoting tumor growth in xenograft models.
Confidence score:

0.6444
Other information
Title:

Circular RNA ACVR2A promotes the progression of hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway.

Journal: Molecular cancer
Published: 2024
PubMed ID: 39107843
Study type:

biological research
Data availability: -
Code availability: -