| Expression pattern: |
UP |
| Associated gene: |
ABCG2 |
| Associated microRNA: |
miR-520h |
| Biological function: |
Promotes cell proliferation, inhibits cell apoptosis, and decreases gefitinib sensitivity in NSCLC cells. |
| Molecular mechanism: |
circSETD3 functions through a competitive endogenous RNA mechanism by directly binding miR-520h and relieving miR-520h-mediated degradation/down-regulation of ABCG2, increasing ABCG2 expression and promoting gefitinib efflux. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); drug resistance (promotes); chemoresistance (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNase R Treatment; RT-qPCR; RNA-seq; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Bioinformatics Analysis |
| Clinical significance: |
circSETD3 can be used as a novel biomarker for lung cancer and gefitinib-acquired resistance. |
| Description: |
hsa_circ_0000567/circSETD3 is up-regulated in gefitinib-resistant NSCLC cell lines. It promotes proliferation, inhibits apoptosis, and contributes to gefitinib resistance through a circSETD3-miR-520h-ABCG2 ceRNA axis, suggesting biomarker potential for lung cancer drug resistance. |
| Confidence score: |
0.6731 |