| Expression pattern: |
UP |
| Associated gene: |
CAMSAP1, 553 mRNA-encoding genes |
| Associated microRNA: |
miR-145-5p |
| Biological function: |
Associated with treatment response (higher in progressive disease after chemotherapy) and potential ceRNA in SCLC; functional validation required. |
| Molecular mechanism: |
Predicted miRNA sponging (ceRNA network) with downstream mRNA targets. |
| Biological pathway or process: |
MAPK (other); apoptosis (other); cellular senescence (other); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Diagnostic biomarker with AUC 0.764 in SCLC; circCAMSAP1 expression significantly associated with chemotherapy response (higher in PD vs PR). |
| Description: |
circCAMSAP1 is significantly up-regulated in SCLC tissues and is analyzed as a predicted ceRNA with 14 interacting miRNAs and 553 downstream mRNA targets. Its expression correlates with chemotherapy response (higher in progressive disease) and has moderate diagnostic accuracy (AUC 0.764), while mechanistic interactions remain computationally predicted. |
| Confidence score: |
0.6895 |