circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): chr11:33307958-33309057:+
Genomic location(hg38): chr11:33286412-33287511:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004976
MONDO name: amyotrophic lateral sclerosis
Disease details: amyotrophic lateral sclerosis / ALS
Disease DO ID:
 332
Disease MeSH ID:
 D000690
Disease NCIt ID:
 C34373
Disease ICD11 ID:
 1982355687
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

spinal cord; quadriceps
Cell lines:

-
In vivo animal model:

genetically engineered animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: HIPK3
Associated microRNA: -
Biological function: -
Molecular mechanism: circRNA/host-gene expression correlation (spinal cord only)
Biological pathway or process:

inflammation (other); myogenesis (other)
Detected method:
Q
Validation methods:

RT-qPCR
Clinical significance:

-
Description:

circHIPK3 is progressively down-regulated in spinal cord during ALS progression (late presymptomatic to terminal) and its expression correlates with HIPK3 host gene levels in spinal cord.
Confidence score:

0.1155
Other information
Title:

Circular RNA expression in ALS is progressively deregulated and tissue-dependent.

Journal: BMC genomics
Published: 2025
PubMed ID: 40596818
Study type:

biological research
Data availability: -
Code availability: -