| Expression pattern: |
UP |
| Associated gene: |
FGF2, STAT3, AKT |
| Associated microRNA: |
miR-7 |
| Biological function: |
UVB-induced ciRS-7 promotes melanogenesis in melanocytes by enhancing paracrine functions of keratinocytes and fibroblasts, including FGF2 expression and secretion. |
| Molecular mechanism: |
ciRS-7 sponges miR-7, activating STAT3 and AKT signaling and promoting FGF2 secretion through a paracrine axis. |
| Biological pathway or process: |
ceRNA regulation (promotes); JAK/STAT (promotes); PI3K/AKT (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; ELISA; Western Blot |
| Clinical significance: |
ciRS-7 may serve as a regulator and potential target for diagnosis and treatment of pigmented skin diseases. |
| Description: |
This study shows that UVB irradiation upregulates ciRS-7 in human keratinocytes and fibroblasts. ciRS-7 promotes melanogenesis through paracrine effects by sponging miR-7, activating STAT3 and AKT signaling, and increasing FGF2 expression and secretion. The authors propose ciRS-7 as a potential regulator and therapeutic or diagnostic target in pigmented skin diseases. |
| Confidence score: |
0.3957 |