circRNA basic information
circBase ID: hsa_circ_0033144
Name: hsa_circ_BCL11B
Synonym: circBCL11B
Host Gene: BCL11B
Genomic location(hg19): chr14:99723807-99724176:-
Genomic location(hg38): chr14:99257470-99257839:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006684
MONDO name: brain edema
Disease details: brain edema
Disease DO ID:
 4724
Disease MeSH ID:
 D001929
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

SVG p12
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: AQP4
Associated microRNA: miR-29b-3p
Biological function: Promotes 1,2-DCE-induced astrocyte swelling and AQP4 upregulation; circBCL11B knockdown alleviates 1,2-DCE-induced AQP4 upregulation and cell swelling.
Molecular mechanism: circBCL11B acts as a competing endogenous RNA and sponges miR-29b-3p, thereby weakening miR-29b-3p-mediated suppression of AQP4 and increasing AQP4 expression.
Biological pathway or process:

ceRNA regulation (promotes); other pathway/process (promotes); mitochondrial function (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; RNase R Treatment; RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Transfection; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

circBCL11B is up-regulated after 1,2-DCE exposure in SVG p12 human astrocyte-like cells. It functions as a ceRNA by binding miR-29b-3p, relieving miR-29b-3p-mediated inhibition of AQP4, thereby promoting AQP4 upregulation and astrocyte swelling. Knockdown of circBCL11B reverses 1,2-DCE-induced AQP4 upregulation and alleviates cell swelling.
Confidence score:

0.6868
Other information
Title:

CircBCL11B acts as a ceRNA to facilitate 1,2-dichloroethane-induced astrocyte swelling via miR-29b-3p/AQP4 axis in SVG p12 cells.

Journal: Toxicology letters
Published: 2023
PubMed ID: 37028497
Study type:

biological research
Data availability: Data will be made available on request; Supplementary data associated with this article can be found in the online version at doi:10.1016/j.toxlet.2023.04.003
Code availability: -