circRNA basic information
circBase ID: hsa_circ_0000515
Name: hsa_circ_RPPH1
Synonym: hsa_circRNA_000585
Host Gene: RPPH1
Genomic location(hg19): chr14:20811305-20811534:-
Genomic location(hg38): chr14:20343146-20343375:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumorous tissue samples; non-tumoruos mammary gland tissue samples; adjacent-non-tumour
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SDC1, CDK1, KIF11
Associated microRNA: miR-486-5p
Biological function: may be an important biomarker candidate in distinguishing patients especially in the BLBC group
Molecular mechanism: predicted miRNA sponge (ceRNA) for miR-486-5p affecting SDC1 axis
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

may be an important biomarker candidate in distinguishing patients especially in the BLBC group
Description:

This study predicts that hsa_circ_0000515 (alias hsa_circRNA_000585) is up-regulated in breast cancer and may act as a miR-486-5p sponge. The proposed ceRNA axis hsa_circ_0000515/miR-486-5p/SDC1 is suggested as a biomarker candidate, particularly for basal-like breast cancer classification.
Confidence score:

0.1768
Other information
Title:

Bioinformatics analysis of the potentially functional circRNA-miRNA-mRNA network in breast cancer.

Journal: PloS one
Published: 2024
PubMed ID: 38635539
Study type:

bioinformatics study
Data availability: GSE101124; GSE182471; GSE25066; TCGA; METABRIC (EGA-S00000000122)
Code availability: -