| Expression pattern: |
UP |
| Associated gene: |
UBE2T, Ago2 |
| Associated microRNA: |
miR‐490‐5p |
| Biological function: |
promotes paclitaxel resistance, proliferation and migration; inhibits apoptosis; promotes tumor growth |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0092887 sponges miR-490-5p to regulate UBE2T |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); drug resistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Wound Healing Assay; Western Blot; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
hsa_circ_0092887 expression was associated with TNM stage and paclitaxel therapy; proposed biomarker for PTX-treated NSCLC |
| Description: |
hsa_circ_0092887 is up-regulated in NSCLC, especially in PTX-resistant tissues and cell lines. It promotes paclitaxel resistance and malignant phenotypes by sponging miR-490-5p and releasing the downstream target UBE2T, thereby enhancing proliferation/migration and inhibiting apoptosis; its knockdown sensitizes cells to PTX and suppresses xenograft growth. |
| Confidence score: |
0.7785 |