circRNA basic information
circBase ID: hsa_circ_0028173
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr12:110764194-110780253:+
Genomic location(hg38): chr12:110326389-110342448:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MG63; U2OS; 143B; HOS; hFOB1.19
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CADM1
Associated microRNA: has-miR-142-5p, has-miR-338-3p
Biological function: Predicted to promote CADM1 expression and promote the development of osteosarcoma.
Molecular mechanism: Predicted ceRNA mechanism as a miRNA sponge (has-miR-142-5p; has-miR-338-3p) to regulate CADM1.
Biological pathway or process:

ceRNA regulation (other); proliferation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Transfection
Clinical significance:

-
Description:

hsa_circ_0028173 is up-regulated in osteosarcoma cell lines and is predicted to sponge has-miR-142-5p and has-miR-338-3p to increase CADM1 expression within a ceRNA network.
Confidence score:

0.3213
Other information
Title:

Circular RNAs hsa_circ_0032462, hsa_circ_0028173, hsa_circ_0005909 are predicted to promote CADM1 expression by functioning as miRNAs sponge in human osteosarcoma.

Journal: PloS one
Published: 2018
PubMed ID: 30153287
Study type:

combined biological and bioinformatics study
Data availability: GSE96964; GSE42352; GSE33382; GSE36001
Code availability: -