| Expression pattern: |
UP |
| Associated gene: |
ANXA2 / Annexin A2 |
| Associated microRNA: |
miR-432 |
| Biological function: |
promotes HCC cell proliferation, migration, invasion, EMT process and tumor growth in vivo |
| Molecular mechanism: |
circ_0021093 acts as a competing endogenous RNA to sponge miR-432 and increase ANXA2 expression |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; H&E Staining; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
high circ_0021093 expression is associated with poor prognosis and unfavorable clinicopathological features in HCC patients; proposed as a promising diagnostic marker and therapeutic target |
| Description: |
circ_0021093 is up-regulated in HCC tissues and cell lines and high expression is associated with poorer overall survival. Functionally, it promotes HCC proliferation, migration, invasion, EMT and xenograft tumor growth by sponging miR-432 and increasing ANXA2 expression. |
| Confidence score: |
0.7126 |