| Expression pattern: |
DN |
| Associated gene: |
PCMTD1 |
| Associated microRNA: |
miR-32-5p |
| Biological function: |
May affect proliferation of lung adenocarcinoma and activate Nature Killer cells. |
| Molecular mechanism: |
May act as a miRNA sponge (ceRNA) for miR-32-5p to regulate PCMTD1. |
| Biological pathway or process: |
proliferation (other); immune regulation (promotes); Wnt/beta-catenin (other); ceRNA regulation (other) |
| Detected method: |
S
M
|
| Validation methods: |
RNA-seq; Microarray; Bioinformatics Analysis |
| Clinical significance: |
May have survival prediction value in the ceRNA network for non-smoking women with lung adenocarcinoma. |
| Description: |
hsa_circ_0072309 (circLIFR) is down-regulated in tumor tissues from non-smoking women with lung adenocarcinoma. The study proposes a ceRNA mechanism where hsa_circ_0072309 sponges miR-32-5p to regulate PCMTD1, potentially affecting tumor proliferation and NK-cell-related activity. |
| Confidence score: |
0.2465 |