| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
CircRNA_101237 may serve as a diagnostic and prognostic biomarker for HCC and is associated with cisplatin resistance; high expression is linked to poorer overall survival and adverse clinicopathological features. |
| Molecular mechanism: |
The molecular mechanism was not elucidated; the study mainly reported upregulation, clinical prognostic association, and association with cisplatin resistance. |
| Biological pathway or process: |
drug resistance (other); chemoresistance (other); metastasis (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
CircRNA_101237 is a diagnostic biomarker for HCC, an independent predictor of survival prognosis, and a biomarker for cisplatin resistance; high expression predicts poorer overall survival. |
| Description: |
CircRNA_101237 is a human CDK8-derived circRNA upregulated in HCC tumor tissues and serum. Its high serum expression is associated with advanced clinicopathological features, poorer overall survival, and cisplatin resistance, supporting its role as a diagnostic/prognostic biomarker and potential therapeutic target, although its molecular mechanism was not determined. |
| Confidence score: |
0.6089 |