| Expression pattern: |
UP |
| Associated gene: |
PMP22 |
| Associated microRNA: |
hsa-miR-1324, hsa-miR-545 |
| Biological function: |
Potential biomarker for GC screening; may be involved in GC progression through a predicted hsa_circ_0067934/hsa-miR-1324/PMP22 network. |
| Molecular mechanism: |
Predicted ceRNA mechanism in which hsa_circ_0067934 may target hsa-miR-1324 and hsa-miR-545 and participate in a hsa_circ_0067934/hsa-miR-1324/PMP22 network. |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Could be a more authentic biomarker for GC screening; the predicted hsa_circ_0067934/hsa-miR-1324/PMP22 network may provide new treatment targets for GC. |
| Description: |
hsa_circ_0067934 was identified as an up-regulated circRNA in gastric cancer by integrated microarray MetaDE analysis and was validated by qRT-PCR in clinical tissues. The study proposes a predicted ceRNA network involving hsa_circ_0067934, hsa-miR-1324, and PMP22 that may be involved in GC progression, supporting its potential as a GC screening biomarker and therapeutic target clue. |
| Confidence score: |
0.4032 |