circRNA basic information
circBase ID: hsa_circ_0062558
Name: hsa_circ_MMP11
Synonym: CircMMP11
Host Gene: MMP11
Genomic location(hg19): chr22:24125597-24126503:+
Genomic location(hg38): chr22:23783410-23784316:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent normal tissues; serum; peripheral whole blood
Cell lines:

Huh7; HepG2; HCCLM3; Hep3B; L02
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: HMGB1
Associated microRNA: miR-361-3p
Biological function: Promotes malignant characteristics of HCC cells (cell viability, migration, invasion) and accelerates malignant progression.
Molecular mechanism: Acts as a miRNA sponge for miR-361-3p to regulate HMGB1 (ceRNA mechanism).
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Transfection; Luciferase Reporter Assay; RNA Pull-Down; CCK8; Transwell Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

High expression of circMMP11 in HCC was associated with patient overall survival; serum circMMP11 had good diagnostic efficacy in distinguishing HCC patients from the control group (AUC 0.9331).
Description:

circMMP11 (hsa_circ_0062558) is up-regulated in HCC tissues/cell lines and promotes HCC malignant behaviors. Mechanistically, it sponges miR-361-3p to increase HMGB1, forming a circMMP11/miR-361-3p/HMGB1 axis. Clinically, high circMMP11 indicates worse prognosis and serum circMMP11 shows strong diagnostic performance for HCC.
Confidence score:

0.7752
Other information
Title:

CircMMP11 as a prognostic biomarker mediates miR-361-3p/HMGB1 axis to accelerate malignant progression of hepatocellular carcinoma.

Journal: Open medicine (Warsaw, Poland)
Published: 2023
PubMed ID: 38025527
Study type:

combined biological and clinical study
Data availability: All data in this study can be obtained by proper request from the authors.
Code availability: -