| Expression pattern: |
UP |
| Associated gene: |
NRBP1, TMEM65, E-cadherin, Vimentin, Snail, Ki67 |
| Associated microRNA: |
miR-497-5p |
| Biological function: |
Promotes PCa cell proliferation, migration, invasion, EMT-related malignant phenotypes, and tumor growth in vivo; high expression is associated with poor prognosis and metastatic clinicopathological features. |
| Molecular mechanism: |
circ_0085494 acts as a miR-497-5p sponge to increase NRBP1 expression, thereby promoting PCa malignant behaviors and regulating EMT-related proteins. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Cohort Study; Survival Analysis; Transfection; Colony Formation Assay; CCK8; EdU Staining; Transwell Assay; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Increased circ_0085494 indicated poor prognosis; circ_0085494 expression was correlated with TNM stage, lymph node metastasis, and distant metastasis, and had independent prognostic value. |
| Description: |
circ_0085494 is up-regulated in prostate cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, EMT-related changes, and xenograft tumor growth by sponging miR-497-5p and increasing NRBP1 expression. Clinically, higher circ_0085494 expression is associated with advanced disease features and poorer prognosis. |
| Confidence score: |
0.8281 |