| Expression pattern: |
UP |
| Associated gene: |
CTNNB1 |
| Associated microRNA: |
miR-375 |
| Biological function: |
circPPP1R12A promotes CC cell proliferation, cell cycle progression, migration, invasion and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circPPP1R12A acts as a ceRNA by sponging miR-375, thereby positively regulating CTNNB1 expression and promoting CC progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); Wnt/beta-catenin (promotes); proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; Wound Healing Assay; Transwell Assay; In Vivo Animal Model |
| Clinical significance: |
circPPP1R12A might be a potential biomarker and therapeutic target for CC. |
| Description: |
circPPP1R12A is up-regulated in colon cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, cell cycle progression, migration, invasion and xenograft tumor growth while suppressing apoptosis, mainly through the circPPP1R12A/miR-375/CTNNB1 ceRNA axis. |
| Confidence score: |
0.7183 |