| Expression pattern: |
DN |
| Associated gene: |
CTNND1, WDPCP |
| Associated microRNA: |
miR-197-3p |
| Biological function: |
Suppresses NSCLC tumorigenesis and inhibits NSCLC cell growth; downregulation of hsa_circ_0003497 may facilitate rapid cancer cell proliferation. |
| Molecular mechanism: |
hsa_circ_0003497 acts as a miR-197-3p sponge, releasing the miR-197-3p target tumor suppressor gene CTNND1 and thereby suppressing NSCLC. |
| Biological pathway or process: |
proliferation (inhibits); ceRNA regulation (other); other pathway/process (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Microarray; Clinical Sample Validation; Bioinformatics Analysis; Transfection |
| Clinical significance: |
Potential molecular marker for prognosis and potential intervention target for treatment of NSCLC, but prognosis data were not available in this study. |
| Description: |
This study identifies hsa_circ_0003497 as a down-regulated circRNA in NSCLC with a tumor-suppressive role. Mechanistically, hsa_circ_0003497 is proposed to sponge miR-197-3p, thereby relieving suppression of the tumor suppressor gene CTNND1 and inhibiting NSCLC cell growth. |
| Confidence score: |
0.5545 |