circRNA basic information
circBase ID: -
Name: hsa_circ_ERBB2
Synonym: novel circ ERBB2
Host Gene: ERBB2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0013792
MONDO name: intracerebral hemorrhage
Disease details: intracerebral hemorrhage / ICH
Disease DO ID:
 -
Disease MeSH ID:
 D002543
Disease NCIt ID:
 -
Disease ICD11 ID:
 873092535
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood cells
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: ERBB2
Associated microRNA: -
Biological function: Novel ICH-specific down-regulated circRNA detected in peripheral blood; included in host-gene functional analysis.
Molecular mechanism: Potential host-gene-related pathway involvement including ERBB receptor signaling network.
Biological pathway or process:

EGFR (other); Wnt/beta-catenin (other); TGF-beta/SMAD (other); PI3K/AKT/mTOR (other); immune regulation (other); other pathway/process (other)
Detected method:
S
Validation methods:

circRNA-seq; RNase R Treatment; Clinical Sample Validation; Cohort Study; Bioinformatics Analysis
Clinical significance:

-
Description:

novel circ ERBB2 was identified as a novel down-regulated circRNA in ICH peripheral blood, with ERBB2 reported as its host gene. Its evidence was sequencing-based, and its potential relevance was inferred from host-gene pathway analysis including ERBB receptor signaling.
Confidence score:

0.5746
Other information
Title:

Identification of circular RNA expression profiles and potential biomarkers for intracerebral hemorrhage.

Journal: Epigenomics
Published: 2021
PubMed ID: 33507103
Study type:

combined biological and clinical study
Data availability: available from corresponding author on reasonable request
Code availability: -