| Expression pattern: |
DN |
| Associated gene: |
KLF6 |
| Associated microRNA: |
miR-630 |
| Biological function: |
circMTO1 inhibits osteosarcoma cell proliferation, migration and invasion, induces apoptosis, and suppresses osteosarcoma progression. |
| Molecular mechanism: |
circMTO1 acts as a sponge for miR-630 and regulates KLF6 through the miR-630/KLF6 axis. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); metastasis (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; Microarray; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; Survival Analysis; Bioinformatics Analysis; In Vivo Animal Model |
| Clinical significance: |
circMTO1 expression correlated with Enneking stage; patients with low circMTO1 expression had significantly shorter overall survival time; circMTO1 may have diagnostic and therapeutic potential in osteosarcoma treatment. |
| Description: |
circMTO1 is down-regulated in osteosarcoma tissues and cell lines, and low expression is associated with poorer overall survival. Functionally, circMTO1 suppresses proliferation, migration, invasion and metastasis-related behavior while promoting apoptosis. Mechanistically, it acts through a ceRNA-like miR-630/KLF6 axis, increasing KLF6 expression by sponging miR-630. |
| Confidence score: |
0.7855 |