| Expression pattern: |
DN |
| Associated gene: |
ATG7 |
| Associated microRNA: |
miR-190b |
| Biological function: |
Induces autophagy, reduces lipid accumulation, and protects endothelial cells from ox-LDL-induced dysfunction in atherosclerosis models. |
| Molecular mechanism: |
circHIPK3 acts through the miR-190b/ATG7 axis to activate autophagy and decrease ox-LDL uptake/lipid accumulation. |
| Biological pathway or process: |
autophagy (promotes); lipid metabolism (inhibits); ceRNA regulation (other); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Western Blot; IF (Immunofluorescence); H&E Staining; Oil Red O Staining; Luciferase Reporter Assay; RNA Pull-Down; Transfection; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circHIPK3 is downregulated in HFD-induced atherosclerotic mice and ox-LDL-treated HUVECs. Its overexpression promotes autophagy and reduces lipid accumulation, apparently through direct targeting of the miR-190b/ATG7 axis, suggesting a protective role in atherosclerosis-related endothelial dysfunction. |
| Confidence score: |
0.627 |