circRNA basic information
circBase ID: hsa_circ_0000051
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr1:35846859-35854683:+
Genomic location(hg38): chr1:35381258-35389082:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: Non-Small-Cell Lung Cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

H1975; HCC827; H1975/OR; HCC827/OR
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Differentially expressed and significantly downregulated in osimertinib-resistant NSCLC cells; no specific functional assays were reported for this circRNA.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RT-qPCR; RNA-seq
Clinical significance:

-
Description:

hsa_circ_0000051 was identified by RNA-Seq and validated by qRT-PCR as significantly downregulated in osimertinib-resistant NSCLC cell lines. The paper did not report functional or mechanistic assays specifically for this circRNA.
Confidence score:

0.1904
Other information
Title:

CircMYBL1 suppressed acquired resistance to osimertinib in non-small-cell lung cancer.

Journal: Cancer genetics
Published: 2024
PubMed ID: 38626533
Study type:

biological research
Data availability: -
Code availability: -