circRNA basic information
circBase ID: hsa_circ_0101996
Name: hsa_circ_SOS2
Synonym: circular RNA salt overly-sensitive 2
Host Gene: SOS2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006143
MONDO name: cervical squamous cell carcinoma
Disease details: cervical squamous cell carcinoma
Disease DO ID:
 3744
Disease MeSH ID:
 -
Disease NCIt ID:
 C4028
Disease ICD11 ID:
 1544785014
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

SCC tissues; adjacent non-tumorous tissues; tumor tissues
Cell lines:

ECT1/E6E7; SiHa; SW756
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: FNDC3B
Associated microRNA: miR-543
Biological function: CircSOS2 promotes proliferation, cell cycle progression, migration, invasion, glycolysis, and tumor growth, while inhibiting apoptosis in SCC.
Molecular mechanism: CircSOS2 functions as an oncogenic circRNA in SCC through a ceRNA-like miR-543/FNDC3B axis, targeting miR-543 and increasing FNDC3B expression.
Biological pathway or process:

proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (promotes); other pathway/process (promotes)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High circSOS2 expression was associated with poor overall survival, low differentiation, positive vascoinvasion, and potential prognostic value in SCC.
Description:

CircSOS2 is up-regulated in human cervical squamous cell carcinoma tissues and cells and high expression predicts poor overall survival. Functionally, circSOS2 promotes SCC cell proliferation, cell cycle progression, migration, invasion, glycolysis, and in vivo tumor growth while suppressing apoptosis. Mechanistically, it acts through the miR-543/FNDC3B axis.
Confidence score:

0.8689
Other information
Title:

CircSOS2 promotes cervical squamous cell carcinoma by regulation of proliferation, cell cycle, apoptosis, migration, invasion, and glycolysis by targeting miR-543/FNDC3B axis.

Journal: Archives of biochemistry and biophysics
Published: 2021
PubMed ID: 34023283
Study type:

combined biological and clinical study
Data availability: -
Code availability: -