circRNA basic information
circBase ID: hsa_circ_0000337
Name: hsa_circ_PPFIA1
Synonym: -
Host Gene: PPFIA1
Genomic location(hg19): chr11:70200406-70202360:+
Genomic location(hg38): chr11:70354300-70356254:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

glioma tissues; normal tissues
Cell lines:

NHA; U251; U87; LN229; T98G
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: MAT2A, PPFIA1
Associated microRNA: miRNA-942-5p
Biological function: promotes proliferation, migration and invasion; accelerates proliferative and metastatic abilities of glioma cells
Molecular mechanism: ceRNA mechanism: hsa_circ_0000337 sponges miRNA-942-5p to upregulate MAT2A
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Actinomycin D / DRB Stability Assay; RNase R Treatment; Transfection; EdU Staining; Transwell Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Bioinformatics Analysis; Survival Analysis; Cohort Study
Clinical significance:

high expression correlates with T3-T4 stage and poor overall survival; potential therapeutic target for glioma
Description:

hsa_circ_0000337 is upregulated in glioma tissues and cell lines, and its high expression is associated with advanced tumor stage and poor overall survival. Functionally, hsa_circ_0000337 promotes glioma cell proliferation, migration and invasion. Mechanistically, it acts as a ceRNA by sponging miRNA-942-5p, thereby upregulating MAT2A and promoting malignant glioma progression.
Confidence score:

0.8271
Other information
Title:

Hsa_circ_0000337 promotes proliferation, migration and invasion in glioma by competitively binding miRNA-942-5p and thus upregulates MAT2A.

Journal: European review for medical and pharmacological sciences
Published: 2020
PubMed ID: 33336744
Study type:

combined biological and clinical study
Data availability: -
Code availability: -