| Expression pattern: |
DN |
| Associated gene: |
EREG, Ago2 |
| Associated microRNA: |
miR-205-5p |
| Biological function: |
Circ_0000078 acts as a tumor suppressor in cervical cancer by restraining cancer cell growth, survival, migration, invasion, and in vivo tumor formation and development. |
| Molecular mechanism: |
Circ_0000078 functions through a ceRNA-like mechanism by targeting miR-205-5p and regulating the downstream miR-205-5p/EREG pathway. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ_0000078 may serve as a potential prognostic biomarker for CC. |
| Description: |
Hsa_circ_0000078/circ_0000078 is downregulated in cervical cancer tissues and cell lines. It acts as a tumor suppressor by inhibiting proliferation, migration, invasion, and xenograft tumor growth while promoting apoptotic activity, mainly through regulation of the miR-205-5p/EREG axis. |
| Confidence score: |
0.7795 |