| Expression pattern: |
UP |
| Associated gene: |
SOD2 |
| Associated microRNA: |
miR-512-5p |
| Biological function: |
promotes NSCLC cell proliferation, migration, and tumor growth |
| Molecular mechanism: |
ceRNA mechanism: circRANGAP1 sponges miR-512-5p to upregulate SOD2 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; Survival Analysis; Clinical Sample Validation |
| Clinical significance: |
High circRANGAP1 expression is associated with advanced clinical stages, lymph node metastasis, and shorter overall survival in NSCLC patients. |
| Description: |
circRANGAP1 is upregulated in NSCLC tissues/cells and promotes proliferation, migration, and xenograft tumor growth. Mechanistically, it acts as a ceRNA to sponge miR-512-5p, thereby increasing SOD2 expression and contributing to NSCLC progression; high circRANGAP1 predicts worse overall survival. |
| Confidence score: |
0.7855 |