| Expression pattern: |
DN |
| Associated gene: |
ADAMTS5, FOXC2, AGO2 |
| Associated microRNA: |
miR-145 |
| Biological function: |
Inhibits HCC cell proliferation, migration and invasion, and suppresses tumor angiogenesis and tumor growth. |
| Molecular mechanism: |
FOXC2 transcriptionally upregulates circ0002898 (from DNAJC16); circ0002898 acts as a cytoplasmic miRNA sponge for miR-145 to relieve repression of ADAMTS5, thereby inhibiting angiogenesis. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); angiogenesis (inhibits); apoptosis (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; ISH (In Situ Hybridization); RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; IHC (Immunohistochemistry); ChIP / ChIP-seq; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low circ0002898 expression correlates with advanced tumor stage/grade and is a biomarker for poor prognosis; ROC analysis indicates diagnostic value (AUC 0.741). |
| Description: |
circ0002898 (from DNAJC16) is down-regulated in HCC and acts as a tumor suppressor. FOXC2 promotes circ0002898 expression, while circ0002898 sponges miR-145 to restore ADAMTS5 expression, thereby inhibiting HCC proliferation/migration/invasion and suppressing tumor angiogenesis; higher circ0002898 associates with better patient survival and has diagnostic value. |
| Confidence score: |
0.8997 |