circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF609
Synonym: circ-ZNF609
Host Gene: ZNF609
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: Colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic and prognostic biomarker for CRC; high expression was correlated with histological grade, lymph node metastasis, and TNM stage.
Molecular mechanism: -
Biological pathway or process:

metastasis (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis
Clinical significance:

Diagnostic accuracy with AUC of 0.8711; high circ-ZNF609 expression was correlated with histological grade, lymph node metastasis, TNM stage, and worse overall survival.
Description:

circ-ZNF609 was significantly up-regulated in serum samples from CRC patients. Its higher expression was associated with advanced clinicopathological features and poorer overall survival, supporting its potential as a diagnostic and prognostic biomarker for CRC.
Confidence score:

0.4758
Other information
Title:

Three CircRNAs Function as Potential Biomarkers for Colorectal Cancer.

Journal: Clinical laboratory
Published: 2020
PubMed ID: 33337836
Study type:

clinical study
Data availability: -
Code availability: -