| Expression pattern: |
DN |
| Associated gene: |
18 DEmRNAs |
| Associated microRNA: |
hsa_miR_346 |
| Biological function: |
May act as a ceRNA in HCC by competitively binding hsa_miR_346 and downregulating 18 DEmRNAs; may be useful for predicting and diagnosing HCC. |
| Molecular mechanism: |
ceRNA mechanism involving circRNA-miRNA-mRNA regulatory network; hsa_circ_0089372 competitively bonds with hsa_miR_346 to downregulate DEmRNA expression. |
| Biological pathway or process: |
ceRNA regulation (other); cell cycle (other); proliferation (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
ROC analysis suggested diagnostic potential; AUC was 1.00 and 1.00 in GSE125469 and GSE128274, respectively. |
| Description: |
hsa_circ_0089372 was identified as a down-regulated HCC-related circRNA by bioinformatic reanalysis of GEO RNA-seq datasets. The study proposes that it may function as a ceRNA by binding hsa_miR_346 and regulating 18 DEmRNAs, with possible relevance to HCC occurrence, progression, and diagnosis. |
| Confidence score: |
0.348 |