| Expression pattern: |
DN |
| Associated gene: |
ITGB1, PSMA4, 26S proteasome |
| Associated microRNA: |
- |
| Biological function: |
Suppresses HCC cell adhesion, migration and metastasis; promotes ITGB1 degradation |
| Molecular mechanism: |
Acts as a protein scaffold/bridge linking ITGB1 to PSMA4/26S proteasome to drive ubiquitination-independent proteasomal degradation of ITGB1 |
| Biological pathway or process: |
migration (inhibits); metastasis (inhibits); invasion (inhibits); PI3K/AKT (inhibits); other pathway/process (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Cohort Study; Survival Analysis; RNA Pull-Down; Western Blot; Transfection; Transwell Assay; In Vivo Animal Model; Bioinformatics Analysis; Microarray |
| Clinical significance: |
Low circPABPC1 expression in tumors correlates with shortened overall survival and disease-free survival (DFS). |
| Description: |
In HCC, circPABPC1 is down-regulated in tumors and acts as a tumor suppressor by inhibiting cell adhesion, migration, and metastasis. Mechanistically, it scaffolds ITGB1 with the 26S proteasome (via PSMA4) to promote ubiquitination-independent proteasomal degradation of ITGB1, dampening downstream FAK/PI3K/Akt signaling. Low circPABPC1 levels are associated with worse OS/DFS, implying potential prognostic and therapeutic relevance. |
| Confidence score: |
0.8428 |