| Expression pattern: |
UP |
| Associated gene: |
IGF2BP2, PD-L1 |
| Associated microRNA: |
- |
| Biological function: |
Promotes proliferation, migration and invasion of NSCLC cells; facilitates immune escape by inhibiting CD4+ and CD8+ T cell proliferation/differentiation. |
| Molecular mechanism: |
CircENTPD7 positively regulates IGF2BP2, which upregulates PD-L1, promoting PD-L1-mediated immune escape in NSCLC cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); immune regulation (promotes); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Transwell Assay; ELISA; Flow Cytometry（Non-apoptosis/cycle） |
| Clinical significance: |
High circENTPD7 levels predicted a lower survival rate of patients with NSCLC. |
| Description: |
CircENTPD7 is up-regulated in NSCLC (H1299 vs BEAS-2B). Its knockdown suppresses NSCLC malignant phenotypes (proliferation, migration, invasion) and it promotes immune escape by modulating the IGF2BP2/PD-L1 axis. |
| Confidence score: |
0.421 |