| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
circRNA-100876 acts as a tumor promoter in colorectal cancer; its inhibition reduces the invasion ability of colorectal cancer cells and its high expression is associated with clinical stage, T classification, lymph node metastasis, and poor overall survival. |
| Molecular mechanism: |
- |
| Biological pathway or process: |
invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Transwell Assay; Survival Analysis |
| Clinical significance: |
High expression of circRNA-100876 was associated with Clinical stage, T classification and Lymph node metastasis of colorectal cancer patients, predicted poor overall survival, and may serve as a new potential biomarker for diagnosis and therapy. |
| Description: |
circRNA-100876 is up-regulated in colorectal cancer tissues and cell lines. High circRNA-100876 expression is associated with advanced clinicopathological features and poor overall survival, while siRNA-mediated knockdown reduces colorectal cancer cell invasion. The study supports circRNA-100876 as a tumor-promoting circRNA and potential diagnostic or therapeutic target in colorectal cancer. |
| Confidence score: |
0.5736 |