| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-1236 |
| Biological function: |
Promotes glioma cell proliferation, clone-forming ability, migration and invasion, and inhibits apoptosis; contributes to malignant progression of glioma. |
| Molecular mechanism: |
circ_001350 acts as a miRNA sponge by directly binding miR-1236 and regulating its expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
Elevated expression of circ_001350 is closely linked to clinical severity, tumor size and WHO grade in glioma patients. |
| Description: |
circ_001350 is up-regulated in glioma tissues and cell lines and is associated with more severe clinicopathological features. Functionally, it promotes glioma cell proliferation, colony formation, migration and invasion while suppressing apoptosis. Mechanistically, circ_001350 acts as a sponge for miR-1236 to facilitate malignant progression of glioma. |
| Confidence score: |
0.6521 |