circRNA basic information
circBase ID: hsa_circ_0005692
Name: hsa_circ_GLIS2
Synonym: CircRNA-5692
Host Gene: GLIS2
Genomic location(hg19): chr16:4382215-4383520:+
Genomic location(hg38): chr16:4332214-4333519:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent non-tumor specimens / para-non-tumor liver tissues; xenograft tumor tissues
Cell lines:

Huh-7; HepG2; HEK293T; HCCLM3; Chang Liver; WR168
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: DAB2IP
Associated microRNA: miR-328-5p
Biological function: tumor suppressor; attenuates malignant behaviors (proliferation, wound healing/migration, invasion) and promotes apoptosis; inhibits EMT; suppresses xenograft tumor growth
Molecular mechanism: ceRNA sponging miR-328-5p to de-repress DAB2IP; associated with decreased DAB2IP promoter methylation in xenograft tumors
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); EMT (inhibits); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; Luciferase Reporter Assay; Transfection; MTT; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; MSP (Methylation-Specific PCR); In Vivo Animal Model; Clinical Sample Validation
Clinical significance:

lower circRNA-5692 expression was significantly associated with abnormal higher levels of AFP, cirrhosis history, larger tumor size, and distant metastasis
Description:

circRNA-5692 is down-regulated in hepatocellular carcinoma and functions as a tumor suppressor. It inhibits proliferation, migration/wound healing, invasion, EMT, and xenograft tumor growth while promoting apoptosis, mainly by sponging miR-328-5p to increase DAB2IP expression.
Confidence score:

0.73
Other information
Title:

CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression.

Journal: Cell death & disease
Published: 2019
PubMed ID: 31776329
Study type:

combined biological and clinical study
Data availability: Supplementary Information accompanies this paper at (10.1038/s41419-019-2089-9).
Code availability: -