| Expression pattern: |
UP |
| Associated gene: |
MTSS1 |
| Associated microRNA: |
miR-141-3p |
| Biological function: |
Promotes metastatic potential (migration/invasion) in liver cancer cells; associated with reduced cumulative survival rate and metastatic progression in hepatitis B virus-infected HCC patients. |
| Molecular mechanism: |
Acts as an endogenous sponge for miR-141-3p (direct binding validated by luciferase reporter assay), antagonizing miR-141-3p to regulate invasive potential/metastasis in HCC cells; a potential downstream pathway involving miR-141-3p target MTSS1 is suggested. |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Transwell Assay |
| Clinical significance: |
High circRNA_100338 expression is associated with lower cumulative survival rate and metastatic clinicopathological parameters (TNM stage, vascular invasion, lung metastasis) in hepatitis B virus-infected HCC patients; proposed as a biomarker for HCC diagnosis and survival estimation. |
| Description: |
circRNA_100338 is significantly up-regulated in hepatitis B-related HCC tissues and correlates with metastatic features and reduced survival. Mechanistically, it directly binds and sponges miR-141-3p (validated by reporter assays), thereby promoting invasion/metastatic potential in liver cancer cells; a potential downstream involvement of MTSS1 is suggested. |
| Confidence score: |
0.7824 |