circRNA basic information
circBase ID: hsa_circ_0067531
Name: hsa_circ_PIK3CB
Synonym: hsacirc_0067531
Host Gene: PIK3CB
Genomic location(hg19): chr3:138413627-138417937:-
Genomic location(hg38): chr3:138694785-138699095:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0000544
MONDO name: mucosal melanoma
Disease details: oral mucosal melanoma / OMM
Disease DO ID:
 0050929
Disease MeSH ID:
 -
Disease NCIt ID:
 C114828
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary tumor; metastatic lymph nodes; paired adjacent normal tissues; non-metastatic nodes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PIK3CB, Sept-9
Associated microRNA: -
Biological function: Associated with metastatic OMM; may serve as a ceRNA regulating OMM tumorigenesis and metastasis; related with activation of MAPK activity.
Molecular mechanism: Bioinformatics-predicted ceRNA mechanism involving circRNA-miRNA interactions and potential mRNA targets; potential involvement in MAPK activation and PIK3CB-related cancer signaling.
Biological pathway or process:

ceRNA regulation (other); MAPK (promotes); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; ROC Analysis
Clinical significance:

Potential diagnostic biomarker for OMM; ROC AUC value was 0.889.
Description:

hsa_circ_0067531 is significantly upregulated in OMM cancerous tissues. It is predicted to participate in ceRNA regulation and is linked to MAPK activation, with ROC analysis suggesting diagnostic potential.
Confidence score:

0.5047
Other information
Title:

Altered expression pattern of circular RNAs in metastatic oral mucosal melanoma.

Journal: American journal of cancer research
Published: 2018
PubMed ID: 30323971
Study type:

combined clinical and bioinformatics study
Data availability: Table S1; Table S2; Table S3
Code availability: -