circRNA basic information
circBase ID: -
Name: hsa_circ_FAT1
Synonym: circFAT1(e2)
Host Gene: FAT1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

osteosarcoma tissue specimens; normal tissue
Cell lines:

SW1353; U2OS; MG-63; hFOB 1.19
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: HK2
Associated microRNA: miR-181b
Biological function: promotes osteosarcoma cell proliferation, migration and invasion
Molecular mechanism: acts as a ceRNA sponge of miR-181b to de-repress HK2 expression
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

circFAT1(e2) is up-regulated in osteosarcoma tissues/cell lines and mainly localizes to the cytoplasm. It promotes osteosarcoma cell proliferation, migration and invasion by sponging miR-181b and thereby increasing HK2 expression (circFAT1(e2)/miR-181b/HK2 ceRNA axis).
Confidence score:

0.6369
Other information
Title:

Circular RNA circFAT1(e2) Promotes Osteosarcoma Progression and Metastasis by Sponging miR-181b and Regulating HK2 Expression.

Journal: BioMed research international
Published: 2020
PubMed ID: 32733938
Study type:

combined biological and clinical study
Data availability: The data used to support the findings of this study are available from the corresponding author upon request.
Code availability: -