| Expression pattern: |
DN |
| Associated gene: |
22 mRNAs, 19 drugs/chemicals |
| Associated microRNA: |
hsa-miR-638 |
| Biological function: |
May function as a competing endogenous RNA and play a vital role in CSCC development; may provide links to therapeutic targets through a circRNA-centered gene regulatory network. |
| Molecular mechanism: |
Potential ceRNA mechanism through hsa-miR-638 in a circRNA-miRNA-mRNA-chemical/drug network. |
| Biological pathway or process: |
ceRNA regulation (other); PI3K/AKT (other); proliferation (other); drug resistance (other); other pathway/process (other) |
| Detected method: |
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis |
| Clinical significance: |
May provide new insight into prognosis and therapy of CSCC, but no direct circRNA-specific survival association was validated. |
| Description: |
hsa circ 0043280 is a downregulated CSCC-associated circRNA derived from TADA2A. The study predicts that it may act as a ceRNA by interacting with hsa-miR-638 and participate in a circRNA-miRNA-mRNA-drug/chemical regulatory network relevant to CSCC biology and therapy. |
| Confidence score: |
0.1768 |