| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-149 |
| Biological function: |
circGFRA1 promotes proliferation, migration and angiogenesis of HCC cells and plays an oncogenic role in HCC. |
| Molecular mechanism: |
circGFRA1 binds miR-149, is negatively correlated with miR-149 expression, and promotes HCC cell proliferation, migration and angiogenesis through the circGFRA1/miR-149 regulatory axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); angiogenesis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Tube Formation Assay |
| Clinical significance: |
High expression of circGFRA1 may lead to poor prognosis in HCC patients; the circGFRA1/miR-149 regulatory axis may be a potential target for clinical diagnosis and treatment of HCC. |
| Description: |
circGFRA1 is up-regulated in HCC tissues and cell lines, and high expression is associated with poor prognosis. Functionally, circGFRA1 promotes HCC cell proliferation, migration and angiogenesis. Mechanistically, circGFRA1 binds miR-149 and acts through the circGFRA1/miR-149 regulatory axis, making it a potential clinical diagnostic and therapeutic target. |
| Confidence score: |
0.7078 |