| Expression pattern: |
UP |
| Associated gene: |
VDAC1, Bax, Bcl-2, CD44, OCT4, SOX2 |
| Associated microRNA: |
miR-330-5p |
| Biological function: |
Promotes proliferation, migration, invasion and self-renewal/stemness of cervical cancer stem cells, and inhibits apoptosis. |
| Molecular mechanism: |
hsa_circ_0007905 acts as a miR-330-5p sponge and mediates VDAC1 expression through a ceRNA mechanism. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); stemness (promotes); apoptosis (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Flow Cytometry（Non-apoptosis/cycle）; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down |
| Clinical significance: |
High hsa_circ_0007905 expression in CC tissues was associated with lymph node metastasis and FIGO stage; it may offer a therapeutic target for treating CC. |
| Description: |
hsa_circ_0007905 is up-regulated in cervical cancer tissues and cervical cancer stem cell-enriched subsets. It promotes CSC proliferation, migration, invasion and self-renewal while suppressing apoptosis by sponging miR-330-5p and thereby regulating VDAC1 expression. High expression is associated with lymph node metastasis and FIGO stage, suggesting potential therapeutic relevance. |
| Confidence score: |
0.8206 |