| Expression pattern: |
UP |
| Associated gene: |
YES1, beta-catenin, c-Myc, CyclinD1 |
| Associated microRNA: |
miR-498 |
| Biological function: |
circ-ZNF124 promotes NSCLC malignant progression; circ-ZNF124 downregulation inhibits cell proliferation and invasion, induces apoptosis and cell cycle arrest, and blocks tumor growth in vivo. |
| Molecular mechanism: |
circ-ZNF124 acts as a sponge of miR-498 to regulate YES1 expression and activates the Wnt/beta-catenin signaling pathway through the circ-ZNF124/miR-498/YES1 axis. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
The therapeutic target of circ-ZNF124 may be a promising approach for the treatment of NSCLC. |
| Description: |
circ-ZNF124 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses NSCLC proliferation, invasion and xenograft tumor growth while inducing apoptosis and cell cycle arrest. Mechanistically, circ-ZNF124 sponges miR-498 to regulate YES1 and activate the Wnt/beta-catenin signaling pathway. |
| Confidence score: |
0.6542 |