circRNA basic information
circBase ID: hsa_circ_0000417
Name: hsa_circ_CPSF6
Synonym: -
Host Gene: CPSF6
Genomic location(hg19): chr12:69644908-69656342:+
Genomic location(hg38): chr12:69251128-69262562:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

liver cancer tissue; adjacent normal liver tissue; HCC tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: WDR76
Associated microRNA: hsa-miR-199a-5p
Biological function: Associated with survival prognosis, immune cell infiltration, immune escape, pathway activity, and HCC diagnosis (as part of the regulatory axis).
Molecular mechanism: ceRNA mechanism (circRNA-miRNA-mRNA regulatory axis).
Biological pathway or process:

ceRNA regulation (other); immune regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis; ROC Analysis
Clinical significance:

Potential diagnostic value for HCC (ROC AUC 0.738).
Description:

hsa_circ_0000417 was identified by microarray-based differential expression and ceRNA-network bioinformatics as an upregulated circRNA in HCC. It is proposed to sponge hsa-miR-199a-5p to regulate WDR76 within a circRNA-miRNA-mRNA axis that shows diagnostic potential in HCC (ROC AUC > 0.7).
Confidence score:

0.348
Other information
Title:

Identification of a novel circRNA-miRNA-mRNA regulatory axis in hepatocellular carcinoma based on bioinformatics analysis.

Journal: Scientific reports
Published: 2023
PubMed ID: 36878930
Study type:

bioinformatics study
Data availability: GSE155949; GSE108724; GSE101728; TCGA
Code availability: -